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pentobarbital will reduce the level or influence of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic effect of elbasvir/grazoprevir can be minimized if coadministered with potent CYP3A inducers and it is thus contraindicated.The efficacy of hormonal contraceptives may very well be lower